Living with the enemy: from protein-misfolding pathologies we know, to those we want to know

نویسندگان

چکیده

Conformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands deficiency (AATD) underdiagnosed. Enemy-aggregating proteins may reside these underdiagnosed AATD patients many a pathology fully develops. In this perspective review, we hypothesize that AAT protein could exert new previously unconsidered biological effect as an endogenous metal ion chelator plays significant role essential homeostasis. respect, polymorphism cause imbalance ions, which be correlated amylin, tau, amyloid beta, alpha synuclein type 2 diabetes mellitus (T2DM), Alzheimer’s Parkinson’s diseases, respectively.

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ژورنال

عنوان ژورنال: Ageing Research Reviews

سال: 2021

ISSN: ['1872-9649', '1568-1637']

DOI: https://doi.org/10.1016/j.arr.2021.101391